Stem cell research for tomorrow's therapies
The focus of the Department of Stem Cell Biology is on modeling diseases of the nervous system. In this context, patient-specific cell models are generated with the aid of human stem cells. Starting from somatic cells of patients, pluripotent stem cells are generated by transformation. Biochemical, neurophysiological and imaging approaches are used to search for disease-specific changes in the patient's own cells. The goal is to better understand disease mechanisms. This knowledge should give a boost to potential therapeutic approaches in the future.
The main research areas of Erlangen Stem Cell Biology are:
- Modeling of sporadic and genetic motor neuron diseases (ALS, HSP).
- Modeling of sporadic and genetic Parkinson's disease
- Modeling of the gut-brain axis