Publikationen

Stammzellbiologie

Leiterin:
Prof. Dr. med. Beate Winner

Publications

2019

Maroni M, Körner J, Schüttler J, Winner B, Lampert A, Eberhardt E. β1 and β3 subunits amplify mechanosensitivity of the cardiac voltage-gated sodium channel Nav1.5. Pflugers Arch. 2019 Dec;471(11-12):1481-1492. doi: 10.1007/s00424-019-02324-w. Epub 2019 Nov 14.

Yilmaz R, Müller K, Brenner D, Volk AE, Borck G, Hermann A, Meitinger T, Strom TM, Danzer KM, Ludolph AC, Andersen PM, Weishaupt JH; German ALS Network MND-NET. SQSTM1/p62 variants in 486 patients with familial ALS from Germany and Sweden. Neurobiol Aging. 2019 Nov 2. pii: S0197-4580(19)30382-3. doi: 10.1016/j.neurobiolaging.2019.10.018.

Sommer A, Marxreiter F, Krach F, Fadler T, Grosch J, Maroni M, Graef D, Eberhardt E, Riemenschneider MJ, Yeo GW, Kohl Z, Xiang W, Gage FH, Winkler J, Prots I, Winner B. Th17 Lymphocytes Induce Neuronal Cell Death in a Human iPSC-Based Model of Parkinson's Disease. Cell Stem Cell. 2019 Jun 6;24(6):1006. doi: 10.1016/j.stem.2019.04.019.

Meents JE, Bressan E, Sontag S, Foerster A, Hautvast P, Rösseler C, Hampl M, Schüler H, Goetzke R, Le TKC, Kleggetveit IP, Le Cann K, Kerth C, Rush AM, Rogers M, Kohl Z, Schmelz M, Wagner W, Jørum E, Namer B, Winner B, Zenke M, Lampert A. The role of Nav1.7 in human nociceptors: insights from human induced pluripotent stem cell-derived sensory neurons of erythromelalgia patients. Pain. 2019 Jun;160(6):1327-1341. doi: 10.1097/j.pain.0000000000001511

Turan S, Boerstler T, Kavyanifar A, Loskarn S, Reis A, Winner B, Lie DC. A novel human stem cell model for Coffin-Siris Syndrome like syndrome reveals the importance of SOX11 dosage for neuronal differentiation and survival. Hum Mol Genet. 2019 Apr 29. pii: ddz089. doi: 10.1093/hmg/ddz089.

Prots I, Winner B. Th17 cells: a promising therapeutic target for Parkinson's disease? Expert Opin Ther Targets. 2019 Apr;23(4):309-314. doi: 10.1080/14728222.2019.1590336. Epub 2019 Mar 14.

Pérez-Brangulí F, Buchsbaum IY, Pozner T, Regensburger M, Fan W, Schray A, Börstler T, Mishra H, Gräf D, Kohl Z, Winkler J, Berninger B, Cappello S, Winner B. Human SPG11 cerebral organoids reveal cortical neurogenesis impairment. Hum Mol Genet. 2019 Mar 15;28(6):961-971. doi: 10.1093/hmg/ddy397.

Kaindl J, Meiser I, Majer J, Sommer A, Krach F, Katsen-Globa A, Winkler J, Zimmermann H, Neubauer JC, Winner B. Zooming in on Cryopreservation of hiPSCs and Neural Derivatives: A Dual-Center Study Using Adherent Vitrification. Stem Cells Transl Med. 2019 Mar;8(3):247-259. doi: 10.1002/sctm.18-0121. Epub 2018 Nov 19.

Kaindl J, Winner B. Disease Modeling of Neuropsychiatric Brain Disorders Using Human Stem Cell-Based Neural Models. Curr Top Behav Neurosci. 2019;42:159-183. doi: 10.1007/7854_2019_111

Namer B, Schmidt D, Eberhardt E, Maroni M, Dorfmeister E, Kleggetveit IP, Kaluza L, Meents J, Gerlach A, Lin Z, Winterpacht A, Dragicevic E, Kohl Z, Schüttler J, Kurth I, Warncke T, Jorum E, Winner B, Lampert A. Pain relief in a neuropathy patient by lacosamide: Proof of principle of clinical translation from patient-specific iPS cell-derived nociceptors. EBioMedicine. 2019 Jan;39:401-408. doi: 10.1016/j.ebiom.2018.11.042. Epub 2018 Nov 28.

 

2018

Pozner T, Schray A, Regensburger M, Lie DC, Schlötzer-Schrehardt U, Winkler J, Turan S, Winner B. Tideglusib Rescues Neurite Pathology of SPG11 iPSC Derived Cortical Neurons. Front Neurosci. 2018 Dec 6;12:914. doi: 10.3389/fnins.2018.00914. eCollection 2018. 

Popp B, Krumbiegel M, Grosch J, Sommer A, Uebe S, Kohl Z, Plötz S, Farrell M, Trautmann U, Kraus C, Ekici AB, Asadollahi R, Regensburger M, Günther K, Rauch A, Edenhofer F, Winkler J, Winner B, Reis A. Need for high-resolution Genetic Analysis in iPSC: Results and Lessons from the ForIPS Consortium. Sci Rep. 2018 Nov 21;8(1):17201. doi: 10.1038/s41598-018-35506-0.

Schäffner I, Minakaki G, Khan MA, Balta EA, Schlötzer-Schrehardt U, Schwarz TJ, Beckervordersandforth R, Winner B, Webb AE, DePinho RA, Paik J, Wurst W, Klucken J, Lie DC. FoxO Function Is Essential for Maintenance of Autophagic Flux and Neuronal Morphogenesis in Adult Neurogenesis. Neuron. 2018 Sep 19;99(6):1188-1203.e6. doi: 10.1016/j.neuron.2018.08.017. Epub 2018 Sep 6.

Krach F, Batra R, Wheeler EC, Vu AQ, Wang R, Hutt K, Rabin SJ, Baughn MW, Libbi RT, Diaz-Garcia S, Stauffer J, Pirie E, Saberi S, Rodriguez M, Madrigal AA, Kohl Z, Winner B, Yeo GW, Ravits J. Transcriptome-pathology correlation identifies interplay between TDP-43 and the expression of its kinase CK1E in sporadic ALS. Acta Neuropathol 2018; doi: 10.1007/s00401-018-1870-7.

Schulze M, Sommer A, Plötz S, Farrell M, Winner B, Grosch J, Winkler J, Riemenschneider MJ. Sporadic Parkinson's disease derived neuronal cells show disease-specific mRNA and small RNA signatures with abundant deregulation of piRNAs. Acta Neuropathol Commun. 2018 Jul 10;6(1):58. doi: 10.1186/s40478-018-0561-x.

Sommer A, Marxreiter F, Krach F, Fadler T, Grosch J, Maroni M, Gräf D, Eberhardt E, Riemenschneider MJ, Yeo GW, Kohl Z, Xiang W, Gage FH, Winkler J, Prots I, Winner B. Th17 lymphocytes induce neuronal cell death in a human iPSC based model of Parkinson’s disease. Cell Stem Cell, 2018, 23, 123-131.

Prots I, Grosch J, Brandis MR, Simmnacher K, Veber V, Havlicek S, Hannapel C, Krach F, Krumbiegel M, Schütz O, Reis A, Wrasidolo W, Galasko D, Grömer T, Masliah E, Schlötzer-Schrehardt U, Xiang W, Winkler J, Winner, B. α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathy.  PNAS, 2018; 115(30):7813.7818.

Regensburger M, Prots I, Reimer D, Brachs S, Loskarn S, Lie DC, Mielenz D, Winner B. Impact of Swiprosin-1/EFhd2 on adult hippocampal neurogenesis. Stem Cell Reports. 2018;10(2):347-355.

Schlachetzki JCM, Prots I, Tao J, Chun HB, Saijo K, Gosselin D, Winner B, Glass CK, Winkler J. A monocyte gene expression signature in the early clinical course of Parkinson‘s disease. Sci Rep. 2018; 8(1):10757. doi: 10.1038/s41598-018-28986-7. Brain Struct Funct. 2018 Apr;223(3):1357-1368. doi: 10.1007/s00429-017-1561-5. Epub 2017 Nov 9.

Regensburger M, Schreglmann SR, Stoll S, Rockenstein E, Loskarn S, Xiang W, Masliah E, Winner B. Oligomer-prone E57K-mutant alpha-synuclein exacerbates integration deficit of adult hippocampal newborn neurons in transgenic mice. 

Schäffner I, Minakaki G, Khan MA, Balta EA, Schlötzer-Schrehardt U, Schwarz TJ, Beckervordersandforth R, Winner B, Webb AE, DePinho R, Paik J, Wurst W, Klucken J, Lie DC. FoxO function is essential for maintenance of autophagic flux and neuronal morphogenesis in adult neurogenesis. In press. Neuron.

 

2017

Sommer A, Winner B, Prots I. The Trojan horse - neuroinflammatory impact of T cells in neurodegenerative diseases. Mol Neurodegener. 2017 Oct 27;12(1):78. doi: 10.1186/s13024-017-0222-8.

Allison R, Edgar JR, Pearson G, Rizo T, Newton T, Günther S, Berner F, Hague J, Connell JW, Winkler J, Lippincott-Schwartz J, Beetz C, Winner B, Reid E. Defects in ER-endosome contacts impact lysosome function in hereditary spastic paraplegia. J Cell Biol, 2017;216(5):1337-1355.

Rothe T, Ipseiz N, Faas M, Lang S, Perez-Branguli F, Metzger D, Ichinose H, Winner B, Schett G, Krönke G. The Nuclear Receptor Nr4a1 Acts as a Microglia Rheostat and Serves as a Therapeutic Target in Autoimmune-Driven Central Nervous System Inflammation. J Immunol, 2017;198(10):3878-3885.

Mielenz D, Reichel M, Jia T, Quinlan EB, Stöckl T, Mettang M, Zilske D, Kirmizi-Alsan E, Schönberger P, Praetner M, Huber SE, Amato D, Schwarz M, Purohit P, Brachs S, Spranger J, Hess A, Büttner C, Ekici AB, Perez-Branguli F, Winner B, Rauschenberger V, Banaschewski T, Bokde AL, Büchel C, Conrod PJ, Desrivières S, Flor H, Frouin V, Gallinat J, Garavan H, Gowland P, Heinz A, Martinot JL, Lemaitre H, Nees F, Paus T, Smolka MN; IMAGEN Consortium, Schambony A, Bäuerle T, Eulenburg V, Alzheimer C, Lourdusamy A, Schumann G, Müller CP. EFhd2/Swiprosin-1 is a common genetic determinator for sensation-seeking/low anxiety and alcohol addiction. Mol Psychiatry, 2017 Apr 11.

Menges S, Minakaki G, Schaefer PM, Meixner H, Prots I, Schlötzer-Schrehardt U, Friedland K, Winner B, Outeiro TF, Winklhofer KF, von Arnim CA, Xiang W, Winkler J, Klucken J. Alpha-synuclein prevents the formation of spherical mitochondria and apoptosis under oxidative stress. Sci Rep. 2017 Feb 22;7:42942. doi: 10.1038/srep42942.

 

2016

Sommer A, Fadler T, Dorfmeister E, Hoffmann AC, Xiang W, Winner B, Prots I, 2016. Infiltrating T lymphocytes reduce myeloid phagocytosis activity in synucleinopathy model. J Neuroinflammation, 2016;13(1):174.

Schulze M, Hoja S, Winner B, Winkler J, Edenhofer F, Riemenschneider MJ ,2016. Model Testing of PluriTest with Next-Generation Sequencing Data. Stem Cells Dev, 2016;25(7):569-71.

Link AS, Kurinna S, Havlicek S, Lehnert S, Reichel M, Kornhuber J, Winner B, Huth T, Zheng F, Werner S, Alzheimer C, 2016. Kdm6b and Pmepa1 as targets of bioelectrically and behaviorally induced Activin A signaling. Mol Neurobiol, 2016;53(6): 4210-25.

Mishra HK, Prots I, Havlicek S, Kohl Z, Perez-Branguli F, Boerstler T, Anneser L, Minakaki G, Wend H, Hampl M, Leone M, Brückner M, Klucken J, Reis A, Boyer L, Schuierer G, Behrens J, Lampert A, Engel FB, Gage FH, Winkler J, Winner B, 2016. GSK3ß-dependent dysregulation of neurodevelopment in SPG11-patient iPSC model. Ann Neurol, 2016; 10.1002/ana.24633.

Salvi R, Steigleder T, Schlachetzki JC, Waldmann E, Schwab S, Winner B, Winkler J, Kohl Z, 2016. Distinct Effects of Chronic Dopaminergic Stimulation on Hippocampal Neurogenesis and Striatal Doublecortin Expression in Adult Mice. Front Neurosci, 2016;10:77.

 

2015

Winner B, Winkler J, 2015. Adult neurogenesis in neurodegenerative diseases. Cold Spring Harb Perspect Biol, 2015;7(4): a021287.

Eberhardt E*, Havlicek S*, Schmidt D*, Link AS, Neacsu C, Kohl Z, Hampl M, Kist AM, Klinger A, Nau C, Schüttler J, Alzheimer C, Winkler J, Namer B, Winner B, Lampert A. Pattern of functional TTX-resistant sodium channels reveals developmental stage of human iPS- and ES cell-derived nociceptors. Stem Cell Reports, 2015;5(3):305-13. *contributed equally

Schreglmann S, Regensburger M, Rockenstein E, Masliah E, Xiang W, Winkler J, Winner B. The temporal expression pattern of alpha-Synuclein modulates olfactory neurogenesis in transgenic mice. PlosOne, 2015;11;10(5):e0126261.

 

2014

Pérez-Brangulí F, Mishra HK, Prots I, Havlicek S, Kohl Z, Saul D, Rummel C, Dorca-Arevalo J, Regensburger M, Graef D, Sock E, Blasi J, Groemer TW, Schlötzer- Schrehardt U, Winkler J, Winner B. Dysfunction of spatacsin leads to axonal pathology in SPG11 linked hereditary spastic paraplegia. HMG, 2014;23(18):4859-74.

Havlicek S, Kohl Z, Mishra HK, Prots I, Eberhardt E, Denguir N, Wend H, Plötz S, Boyer S, Marchetto MCN, Aigner S, Sticht H, Groemer TW, Hehr U, Lampert A, Schlötzer-Schrehardt U, Winkler J, Gage FH, Winner B. Gene dosage dependent rescue of HSP neurite defects in SPG4 patients’ neurons. HMG, 2014; 23(10):2527-41.

Franz S, Ciatipis M, Pfeifer K, Kierdorf B, Sandner B, Bogdahn U, Blesch A, Winner B, Weidner N, 2014. Thoracic Rat Spinal Cord Contusion Injury Induces Remote Spinal Gliogenesis but Not Neurogenesis or Gliogenesis in the Brain. PLoS ONE, 2014;9(7): e102896.

Schlachetzki JCM, Marxreiter F, Regensburger M, Kulinich A, Winner B, Winkler J, 2014. Increased tyrosine hydroxylase expression accompanied by glial changes within the non-lesioned hemisphere in the 6-hydroxydopamine model of Parkinson's disease. Restor Neurol Neurosci, 2014;32(4): 447-62.

Regensburger M, Prots I, Winner B. Adult Hippocampal Neurogenesis in Parkinson's Disease: Impact on Neuronal Survival and Plasticity. Neural Plast, 2014;2014: 454696.

Purohit P*, Perez-Branguli F*, Prots I*, Borger E, Gunn-Moore F, Welzel O, Loy K, Wenzel EM, Grömer TW, Brachs S, Holzer M, Buslei R, Fritsch K, Regensburger M, Böhm KJ, Winner B, Mielenz D. The Ca2+ sensor protein Swiprosin-1/EFhd2 is present in neurites and involved in kinesin-mediated transport in neurons. Plos One, 2014; 9(8):e103976. *contributed equally

Ettle B, Reiprich S, Deusser J, Schlachetzki JC, Xiang W, Prots I, Masliah E, Winner B, Wegner M, Winkler J. Intracellular alpha-synuclein affects early maturation of primary oligodendrocyte progenitor cells. Molecular and Cellular Neuroscience, 2014;62:68-78.

Ettle B, May VEL, Reiprich S, Xiang W, Winner B, Wegner M, Masliah E, Winkler J, 2014. Impaired maturation of oligodendrocyte precursors in multiple system atrophy. Mov Disord, 2014;29 1: S9-S10.

May VE, Ettle B, Poehler AM, Nuber S, Ubhi K, Rockenstein E, Winner B, Wegner M, Masliah E, Winkler J. Alpha-synuclein impairs oligodendrocyte progenitor maturation in multiple system atrophy. Neurobiol Aging, 2014;35(10):2357-68.

Rockenstein E, Nuber S, Overk CR, Ubhi K, Mante M, Patrick C, Adame A, Trejo-Morales M, Riek R, Winkler J, Gage FH, Winner B, Masliah E. Synaptic accumulation of oligomer prone a-synuclein exacerbates synapto-degeneration and neuronal loss in a transgenic mouse model. Brain, 2014;137(5):1496-513.

 

2013

Marxreiter F, Ettle B, May VE, Esmer H, Patrick C, Kragh CL, Klucken J, Winner B, Riess O, Winkler J, Masliah E, Nuber S. Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice. Neurobiol Dis, 2013;59:38-51.

Prots I, Veber V, Brey S, Campioni S, Buder K, Riek R, Böhm KJ, Winner B. Alpha-synuclein oligomers impair neuronal microtubule-kinesin interplay. J Biol Chem, 2013;288: 21742-21754.

 

2012

Winner B, Regensburger M, Schreglmann S. Boyer L, Prots I, Rockenstein E, ManteM, Zhao C, Winkler J, Masliah E, Gage FH. Role of α-synuclein in adult neurogenesis and neuronal maturation in the dentate gyrus. J Neurosci, 2012; 32(47):16906-16916.

May VE, Nuber S, Marxreiter F, Riess O, Winner B, Winkler J. Impaired olfactory bulb neurogenesis depends on the presence of human wild-type alpha-synuclein. Neurosci; 2012; 11;222:343-55.

Desplats, P, Spencer, B , Crews, L, Pathel, P, Morvinski-Friedmann, D, Kosberg, K, Roberts, S, Patrick, C ,Winner, B, Winkler, J, Masliah, E. Alpha-Synuclein Induces Alterations in Adult Neurogenesis in Parkinson Disease Models via p53-mediated Repression of Notch1. J Bio Chem, 2012; 287(38): 31691-702.

Hinkle KM, Yue M, Behrouz B, Dächsel JC, Lincoln SJ, Bowles EE, Beevers JE, Dugger B, Winner B, Prots I, Kent CB, Nishioka K, Lin WL, Dickson DW, Janus CJ, Farrer MJ, Melrose HL. LRRK2 knockout mice have an intact dopaminergic system but display alterations in exploratory and motor coordination behaviors. Mol Neurodegen, 2012;30;7:25.

 

2011

Winner B, Kohl Z, Gage FH. Neurodegenerative disease and adult neurogenesis. Eur J Neurosci, 2011;33(6):1139-51.

Winner B, Jappelli R, Maji SK, Desplats PA, Boyer L, Aigner S, Hetzer C, Loher T, Vilar M, Campioni S, Tzitzilonis C, Soragni A, Jessberger S, Mira H, Consiglio A, Pham E, Masliah E, Gage FH, Riek R. In vivo demonstration that alpha-synuclein oligomers are toxic. Proc Natl Acad Sci U S A, 2011;108(10):4194-9.

 
Kontakt

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91054 Erlangen

Telefon: 09131 85-39310
Fax: 09131 85-85-39311
E-Mail: beate.winneratuk-erlangen.de
Homepage: www.stammzellbiologie.uk-erlangen.de