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PhD Absolventen

Johanna Kaindl

"Advances in human stem cell-based disease models of neurodegeneration"

 

Publikationen

Krumm, L., Pozner, T., Kaindl, J., Regensburger, M., Gunther, C., Turan, S., . . . Winner, B. (2021). Generation and characterization of an endogenously tagged SPG11-human iPSC line by CRISPR/Cas9 mediated knock-in. Stem Cell Res, 56, 102520.

Simmnacher K*, Lanfer J*, Rizo T*, Kaindl J*, Winner B (2019) Modeling Cell-Cell Interactions in Parkinson’s Disease Using Human Stem Cell-Based Models. Front Cell Neurosci 13: 571. doi: 10.3389/fncel.2019.00571 *contributed equally

Kaindl J, Winner B (2019) Disease Modeling of Neuropsychiatric Brain Disorders Using Human Stem Cell-Based Neural Models. Curr Top Behav Neurosci 42: 159-183. doi: 10.1007/7854_2019_111

Kaindl J*, Meiser I*, Majer J*, Sommer A, Krach F, Katsen-Globa A, Winkler J, Zimmermann H, Neubauer JC, Winner B. Zooming in on Cryopreservation of hiPSCs and Neural Derivatives: A Dual-Center Study Using Adherent Vitrification. Stem Cells Transl Med. 2018 Nov 19. doi: 10.1002/sctm.18-0121. *contributed equally


Tatyana Pozner

"Exploring the cellular and molecular mechanisms of the neurodegenerative phenotype in SPG11"

 

Publikationen

Krumm, L., Pozner, T., Kaindl, J., Regensburger, M., Gunther, C., Turan, S., . . . Winner, B. (2021). Generation and characterization of an endogenously tagged SPG11-human iPSC line by CRISPR/Cas9 mediated knock-in. Stem Cell Res, 56, 102520.

Moaraf S, Vistoropsky Y, Pozner T, Heiblum R, Okuliarová M, Zeman M, Barnea A (2020) Artificial light at night affects brain plasticity and melatonin in birds. Neurosci Lett. Jan 18;716:134639. doi: 10.1016/j.neulet.2019.134639.

Güner F, Pozner T, Krach F, Prots I, Loskarn L, Schlötzer-Schrehardt U, Winkler J, Winner B, Regensburger M (2021) Axon-Specific Mitochondrial Pathology in SPG11 Alpha Motor Neurons. Front. Neurosci. 15:680572. doi: 10.3389/fnins.2021.680572.

Pozner T*, Regensburger M*, Engelhorn T, Winkler J, Winner B (2020) Janus-faced spatacsin (SPG11): involvement in neurodevelopment and multisystem neurodegeneration. Brain. 2020 May 1;awaa099. doi: 10.1093/brain/awaa099. Online ahead of print. *Equal contribution

Cerrone F, Pozner T, Siddiqui A, Ceppi P, Winner B, Rajendiran M, Babu R, Ibrahim HS, Rodriguez BJ, Winkler J, Murphy KJ, O’Connor KE (2020) Polyhydroxyphenylvalerate/polycaprolactone nanofibers improve the life-span and mechanoresponse of human IPSC-derived cortical neuronal cells. Mater Sci Eng C Mater Biol Appl 111: 110832. doi: 10.1016/j.msec.2020.110832

Pozner T*, Schray A*, Regensburger M, Lie DC, Schlötzer-Schrehardt U, Winkler J, Turan S, Winner B. Tideglusib Rescues Neurite Pathology of SPG11 iPSC Derived Cortical Neurons. Front Neurosci. 2018 Dec 6;12:914. doi: 10.3389/fnins.2018.00914. eCollection 2018. *Equal contribution

Pérez-Brangulí F*, Buchsbaum IY*, Pozner T*, Regensburger M, Fan W, Schray A, Börstler T, Mishra H, Gräf D, Kohl Z, Winkler J, Berninger B, Cappello S, Winner B. Human SPG11 cerebral organoids reveal cortical neurogenesis impairment. Hum Mol Genet. 2018 Nov 22. doi: 10.1093/hmg/ddy397. *Equal contribution

Pozner T, Vistoropsky Y, Moaraf S, Heiblum R, Barnea A. Questioning Seasonality of Neuronal Plasticity in the Adult Avian Brain. Sci Rep. 2018 Jul 26;8(1):11289. doi: 10.1038/s41598-018-29532-1.

Toren A, Pismenyuk T, Yalon M, Freedman S, Simon AJ, Fisher T, Moshe I, Reichardt JK, Constantini S, Mardor Y, Last D, Guez D, Daniels D, Assoulin M, Mehrian-Shai R. Zinc enhances temozolomide cytotoxicity in glioblastoma multiforme model systems. Oncotarget. 2016 Nov 15;7(46):74860-74871. doi: 10.18632/oncotarget.11382.

Mehrian-Shai R, Yalon M, Simon AJ, Eyal E, Pismenyuk T, Moshe I, Constantini S, Toren A. High metallothionein predicts poor survival in glioblastoma multiforme. BMC Med Genomics. 2015 Oct 22;8:68. doi: 10.1186/s12920-015-0137-6.


Tania Rizo

"Modelling Endoplasmic Reticulum Pathology in Hereditary Spastic Paraplegia 4 using human iPSC derived Cortical Motor Neurons"

 

Publikationen

Simmnacher K*, Lanfer J*, Rizo T*, Kaindl J*, Winner B (2019) Modeling Cell-Cell Interactions in Parkinson’s Disease Using Human Stem Cell-Based Models. Front Cell Neurosci 13: 571. doi: 10.3389/fncel.2019.00571 * equal contribution

Newton T, Allison R, Edgar JR, Lumb JH, Rodger CE, Manna PT, Rizo T, Kohl Z, Nygren AOH, Arning L, Schüle R, Depienne C, Goldberg L, Frahm C, Stevanin G, Durr A, Schöls L, Winner B, Beetz C, Reid E. Mechanistic basis of an epistatic interaction reducing age at onset in hereditary spastic paraplegia. Brain. 2018 May 1;141(5):1286-1299. doi: 10.1093/brain/awy034.

Allison R, Edgar JR, Pearson G, Rizo T, Newton T, Günther S, Berner F, Hague J, Connell JW, Winkler J, Lippincott-Schwartz J, Beetz C, Winner B, Reid E. Defects in ER-endosome contacts impact lysosome function in hereditary spastic paraplegia. J Cell Biol. 2017 May 1;216(5):1337-1355. doi: 10.1083/jcb.201609033. Epub 2017 Apr 7.

Johann S, Heitzer M, Kanagaratnam M, Goswami A, Rizo T, Weis J, Troost D, Beyer C. NLRP3 inflammasome is expressed by astrocytes in the SOD1 mouse model of ALS and in human sporadic ALS patients. Glia. 2015 Dec;63(12):2260-73. doi: 10.1002/glia.22891. Epub 2015 Jul 21.


Katrin Simnacher

"Analyzing the role of aging and alpha-synuclein in the neurodegenerative process of Parkinson´s disease"

 

Publikationen

Simmnacher K, Krach F, Schneider Y, Alecu JE, Mautner L, Klein P, Roybon L, Prots I, Xiang W, Winner B. Unique signatures of stress-induced senescent human astrocytes. Exp Neurol. 2020 Dec;334:113466. doi: 10.1016/j.expneurol.2020.113466. Epub 2020 Sep 17. PMID: 32949572.

Brazdis RM, Alecu J, Marsch D, Dahms A, Simmnacher K, Lorentz S, Brendler A, Schneider Y, Marxreiter F, Roybon L, Winner B, Xiang W, Prots I (2020) Demonstration of brain region-specific neuronal vulnerability in human iPSC-based model of familial Parkinson’s disease. Hum Mol Genet pii: ddaa039. doi: 10.1093/hmg/ddaa039

Simmnacher K*, Lanfer J*, Rizo T*, Kaindl J*, Winner B (2019) Modeling Cell-Cell Interactions in Parkinson’s Disease Using Human Stem Cell-Based Models. Front Cell Neurosci 13: 571. doi: 10.3389/fncel.2019.00571

Prots I, Grosch J, Brazdis RM, Simmnacher K, Veber V, Havlicek S, Hannappel C, Krach F, Krumbiegel M, Schütz O, Reis A, Wrasidlo W, Galasko DR, Groemer TW, Masliah E, Schlötzer-Schrehardt U, Xiang W, Winkler J, Winner B. α-Synuclein oligomers induce early axonal dysfunction in human iPSC-based models of synucleinopathies. Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7813-7818. doi: 10.1073/pnas.1713129115. Epub 2018 Jul 10., PMID: 29991596