Publikationen

Marxreiter, F., Lambrecht, V., Mennecke, A., Hanspach, J., Jukic, J., Regensburger, M., Herrler, J., German, A., Kassubek, J., Gron, G., Muller, H. P., Laun, F. B., Dorfler, A., Winkler, J., & Schmidt, M. A. (2023). Parkinson's disease or multiple system atrophy: potential separation by quantitative susceptibility mapping. Ther Adv Neurol Disord, 16, 17562864221143834. https://doi.org/10.1177/17562864221143834

Asadollahi, R., Delvendahl, I., Muff, R., Tan, G., Rodriguez, D. G., Turan, S., Russo, M., Oneda, B., Joset, P., Boonsawat, P., Masood, R., Mocera, M., Ivanovski, I., Baumer, A., Bachmann-Gagescu, R., Schlapbach, R., Rehrauer, H., Steindl, K., Begemann, A., Reis, A., Winkler, J., Winner, B., Müller, M., Rauch, A. (2023). Pathogenic SCN2A variants cause early-stage dysfunction in patient-derived neurons. Hum Mol Genet. https://doi.org/10.1093/hmg/ddad048

Masanetz, R. K., Baum, W., Schett, G., Winkler, J., & Suss, P. (2023). Cellular plasticity and myeloid inflammation in the adult brain are independent of the transcriptional modulator DREAM. Neurosci Lett, 796, 137061. https://doi.org/10.1016/j.neulet.2023.137061

Schaffner, I., Wittmann, M. T., Vogel, T., & Lie, D. C. (2023). Differential vulnerability of adult neurogenic niches to dosage of the neurodevelopmental-disorder linked gene Foxg1. Mol Psychiatry, 28(1), 497-514. https://doi.org/10.1038/s41380-022-01497-8

Akdas, E. Y., Turan, S., Guhathakurta, D., Ekici, A., Salar, S., Lie, D. C., Winner, B., & Fejtova, A. (2023). CRISPR/Cas9-mediated generation of hESC lines with homozygote and heterozygote p.R331W mutation in CTBP1 to model HADDTS syndrome. Stem Cell Res, 67, 103012. https://doi.org/10.1016/j.scr.2022.103012

Lanfer, J., Kaindl, J., Krumm, L., Gonzalez Acera, M., Neurath, M., Regensburger, M., Krach, F., & Winner, B. (2022). Efficient and Easy Conversion of Human iPSCs into Functional Induced Microglia-like Cells. Int J Mol Sci, 23(9). https://doi.org/10.3390/ijms23094526

Stern, S., Lau, S., Manole, A., Rosh, I., Percia, M. M., Ben Ezer, R., Shokhirev, M. N., Qiu, F., Schafer, S., Mansour, A. A., Mangan, K. P., Stern, T., Ofer, P., Stern, Y., Diniz Mendes, A. P., Djamus, J., Moore, L. R., Nayak, R., Laufer, S. H., Aicher, A., Rhee, A., Wong T. L., Nguyen, T., Linker, S. B., Winner, B., Freitas, B. C., Jones, E., Sagi, I., Bardy, C., Brice, A., Winkler, J., Marchetto, M. C., Gage, F. H. (2022). Reduced synaptic activity and dysregulated extracellular matrix pathways in midbrain neurons from Parkinson's disease patients. NPJ Parkinsons Dis, 8(1), 103. https://doi.org/10.1038/s41531-022-00366-z

Pieger, K., Schmitt, V., Gauer, C., Giessl, N., Prots, I., Winner, B., Winkler, J., Brandstatter, J. H., & Xiang, W. (2022). Translocation of Distinct Alpha Synuclein Species from the Nucleus to Neuronal Processes during Neuronal Differentiation. Biomolecules, 12(8). https://doi.org/10.3390/biom12081108

Schmidt, S., Luecken, M. D., Trumbach, D., Hembach, S., Niedermeier, K. M., Wenck, N., Pflugler, K., Stautner, C., Bottcher, A., Lickert, H., Ramirez-Suastegui, C., Ahmad, R., Ziller, M. J., Fitzgerald, J. C., Ruf, V., van de Berg, W. D. J., Jonker, A. J., Gasser, T., Winner, B., Winkler, J., Vogt Weisenhorn, D. M., Giesert, F., Theis, F. J., Wurst, W. (2022). Primary cilia and SHH signaling impairments in human and mouse models of Parkinson's disease. Nat Commun, 13(1), 4819. https://doi.org/10.1038/s41467-022-32229-9

Schneider, Y., Turan, S., Koller, A., Krumbiegel, M., Farrell, M., Plotz, S., Winkler, J., & Xiang, W. (2022). Generation of a homozygous and a heterozygous SNCA gene knockout human-induced pluripotent stem cell line by CRISPR/Cas9 mediated allele-specific tuning of SNCA expression. Stem Cell Res, 65, 102952. https://doi.org/10.1016/j.scr.2022.102952

Seebauer, L., Schneider, Y., Drobny, A., Plotz, S., Koudelka, T., Tholey, A., Prots, I., Winner, B., Zunke, F., Winkler, J., & Xiang, W. (2022). Interaction of Alpha Synuclein and Microtubule Organization Is Linked to Impaired Neuritic Integrity in Parkinson's Patient-Derived Neuronal Cells. Int J Mol Sci, 23(3). https://doi.org/10.3390/ijms23031812

Luecken, M. D., Buttner, M., Chaichoompu, K., Danese, A., Interlandi, M., Mueller, M. F., Strobl, D. C., Zappia, L., Dugas, M., Colome-Tatche, M., & Theis, F. J. (2022). Benchmarking atlas-level data integration in single-cell genomics. Nat Methods, 19(1), 41-50. https://doi.org/10.1038/s41592-021-01336-8

Dederer, H. G., & Hamburger, D. (2022). Are genome-edited micro-organisms covered by Directive 2009/41/EC?-implications of the CJEU's judgment in the case C-528/16 for the contained use of genome-edited micro-organisms. J Law Biosci, 9(1), lsab033. https://doi.org/10.1093/jlb/lsab033

Triebelhorn, J., Cardon, I., Kuffner, K., Bader, S., Jahner, T., Meindl, K., Rothhammer-Hampl, T., Riemenschneider, M. J., Drexler, K., Berneburg, M., Nothdurfter, C., Manook, A., Brochhausen, C., Baghai, T. C., Hilbert, S., Rupprecht, R., Milenkovic, V. M., & Wetzel, C. H. (2022). Induced neural progenitor cells and iPS-neurons from major depressive disorder patients show altered bioenergetics and electrophysiological properties. Mol Psychiatry. https://doi.org/10.1038/s41380-022-01660-1

L Sikkema, D Strobl, L Zappia, E Madissoon, NS Markov, L Zaragosi, M Ansari, M Arguel, L Apperloo, C Bécavin, M Berg, E Chichelnitskiy, M Chung, A Collin, ACA Gay, B Hooshiar Kashani, M Jain, T Kapellos, TM Kole, C Mayr, M von Papen, L Peter, C Ramírez-Suástegui, J Schniering, C Taylor, T Walzthoeni, C Xu, LT Bui, C de Donno, L Dony, M Guo, AJ Gutierrez, L Heumos, N Huang, I Ibarra, N Jackson, P Kadur Lakshminarasimha Murthy, M Lotfollahi, T Tabib, C Talavera-Lopez, K Travaglini, A Wilbrey-Clark, KB Worlock, M Yoshida, Lung Biological Network Consortium, T Desai, O Eickelberg, C Falk, N Kaminski, M Krasnow, R Lafyatis, M Nikolíc, J Powell, J Rajagopal, O Rozenblatt-Rosen, MA Seibold, D Sheppard, D Shepherd, SA Teichmann, A Tsankov, J Whitsett, Y Xu, NE Banovich, P Barbry, TE Duong, KB Meyer, JA Kropski, D Pe’er, HB Schiller, PR Tata, JL Schultze, AV Misharin, MC Nawijn, MD Luecken, F Theis bioRxiv 2022.03.10.483747; doi: https://doi.org/10.1101/2022.03.10.483747

Prieto Huarcaya, S., Drobny, A., Marques, A. R. A., Di Spiezio, A., Dobert, J. P., Balta, D., Werner, C., Rizo, T., Gallwitz, L., Bub, S., Stojkovska, I., Belur, N. R., Fogh, J., Mazzulli, J. R., Xiang, W., Fulzele, A., Dejung, M., Sauer, M., Winner, B., Rose-John, S., Arnold, P., Saftig, P., Zunke, F. (2022). Recombinant pro-CTSD (cathepsin D) enhances SNCA/alpha-Synuclein degradation in alpha-Synucleinopathy models. Autophagy, 18(5), 1127-1151. https://doi.org/10.1080/15548627.2022.2045534

Krach, F., Stemick, J., Boerstler, T., Weiss, A., Lingos, I., Reischl, S., Meixner, H., Ploetz, S., Farrell, M., Hehr, U., Kohl, Z., Winner, B., & Winkler, J. (2022). An alternative splicing modulator decreases mutant HTT and improves the molecular fingerprint in Huntington's disease patient neurons. Nat Commun, 13(1), 6797. https://doi.org/10.1038/s41467-022-34419-x

Lieke Michielsen, Mohammad Lotfollahi, Daniel Strobl, Lisa Sikkema, Marcel J.T. Reinders, Fabian J. Theis, Ahmed Mahfouz. bioRxiv 2022.07.07.499109; doi: https://doi.org/10.1101/2022.07.07.499109

Battis, K., Florio, J. B., Mante, M., Lana, A., Naumann, I., Gauer, C., Lambrecht, V., Muller, S. J., Cobo, I., Fixsen, B., Kim, H. Y., Masliah, E., Glass, C. K., Schlachetzki, J. C. M., Rissman, R. A., Winkler, J., & Hoffmann, A. (2022). CSF1R-Mediated Myeloid Cell Depletion Prolongs Lifespan But Aggravates Distinct Motor Symptoms in a Model of Multiple System Atrophy. J Neurosci, 42(40), 7673-7688. https://doi.org/10.1523/JNEUROSCI.0417-22.2022

van den Hurk, M., Lau, S., Marchetto, M. C., Mertens, J., Stern, S., Corti, O., Brice, A., Winner, B., Winkler, J., Gage, F. H., & Bardy, C. (2022). Druggable transcriptomic pathways revealed in Parkinson's patient-derived midbrain neurons. NPJ Parkinsons Dis, 8(1), 134. https://doi.org/10.1038/s41531-022-00400-0

Gunther, C., Winner, B., Neurath, M. F., & Stappenbeck, T. S. (2022). Organoids in gastrointestinal diseases: from experimental models to clinical translation. Gut, 71(9), 1892-1908. https://doi.org/10.1136/gutjnl-2021-326560

Krach, F., Wheeler, E. C., Regensburger, M., Boerstler, T., Wend, H., Vu, A. Q., Wang, R., Reischl, S., Boldt, K., Batra, R., Aigner, S., Ravits, J., Winkler, J., Yeo, G. W., & Winner, B. (2022). Aberrant NOVA1 function disrupts alternative splicing in early stages of amyotrophic lateral sclerosis. Acta Neuropathol, 144(3), 413-435. https://doi.org/10.1007/s00401-022-02450-3

Masanetz, R. K., Winkler, J., Winner, B., Gunther, C., & Suss, P. (2022). The Gut-Immune-Brain Axis: An Important Route for Neuropsychiatric Morbidity in Inflammatory Bowel Disease. Int J Mol Sci, 23(19).https://doi.org/10.3390/ijms231911111

Seebauer, L.; Schneider, Y.; Drobny, A.; Plötz, S.; Koudelka, T.; Tholey, A.; Prots, I.; Winner, B.; Zunke, F.; Winkler, J.; et al. Interaction of Alpha Synuclein and Microtubule Organization Is Linked to Impaired Neuritic Integrity in Parkinson’s Patient-Derived Neuronal Cells. Int. J. Mol. Sci.2022, 23, 1812. https://doi.org/10.3390/ijms23031812

Huarcaya, S. P., Drobny, A., Marques, A. R. A., Di Spiezio, A., Dobert, J. P., Balta, D., Werner, C., Rizo, T., Gallwitz, L., Bub, S., Stojkovska, I., Belur, N. R., Fogh, J., Mazzulli, J. R., Xiang, W.,  Fulzele, A., Dejung, M., Sauer, M., Winner, B., Rose-John, S., Arnold, P., Saftig, P., Zunke, F. (2022) Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-Synucleinopathy models, Autophagy, 18:5, 1127-1151, DOI: 10.1080/15548627.2022.2045534

Zunke, F., Winner, B., Richter, F., & Caraveo, G. (2021). Editorial: Intracellular Mechanisms of alpha-Synuclein Processing. Front Cell Dev Biol, 9, 752378. https://doi.org/10.3389/fcell.2021.752378

Wolff, H., & Kunz, A. (2021). [Not Available]. Medizinrecht, 39(9), 800-808. https://doi.org/10.1007/s00350-021-5977-9 (Hirnorganoide - Ethische Herausforderungen und ihre Berucksichtigung und Umsetzung im Recht.)

Guner, F., Pozner, T., Krach, F., Prots, I., Loskarn, S., Schlotzer-Schrehardt, U., Winkler, J., Winner, B., & Regensburger, M. (2021). Axon-Specific Mitochondrial Pathology in SPG11 Alpha Motor Neurons. Front Neurosci, 15, 680572. https://doi.org/10.3389/fnins.2021.680572

Mészáros, L., Riemenschneider, M. J., Gassner, H., Marxreiter, F., von Hörsten, S., Hoffmann, A., & Winkler, J. (2021). Human alpha-synuclein overexpressing MBP29 mice mimic functional and structural hallmarks of the cerebellar subtype of multiple system atrophy. Acta Neuropathol Commun, 9(1), 68. https://doi.org/10.1186/s40478-021-01166-x

Gunther, C., Rothhammer, V., Karow, M., Neurath, M., & Winner, B. (2021). The Gut-Brain Axis in Inflammatory Bowel Disease-Current and Future Perspectives. Int J Mol Sci, 22(16). https://doi.org/10.3390/ijms22168870

Fischer, D. S., Dony, L., Konig, M., Moeed, A., Zappia, L., Heumos, L., Tritschler, S., Holmberg, O., Aliee, H., & Theis, F. J. (2021). Sfaira accelerates data and model reuse in single cell genomics. Genome Biol, 22(1), 248. https://doi.org/10.1186/s13059-021-02452-6

Wittmann, M. T., Katada, S., Sock, E., Kirchner, P., Ekici, A. B., Wegner, M., Nakashima, K., Lie, D. C., & Reis, A. (2021). scRNA sequencing uncovers a TCF4-dependent transcription factor network regulating commissure development in mouse. Development, 148(14). https://doi.org/10.1242/dev.196022

Buttner, M., Ostner, J., Muller, C. L., Theis, F. J., & Schubert, B. (2021). scCODA is a Bayesian model for compositional single-cell data analysis. Nat Commun, 12(1), 6876. https://doi.org/10.1038/s41467-021-27150-6

Krumm, L., Pozner, T., Kaindl, J., Regensburger, M., Gunther, C., Turan, S., Asadollahi, R., Rauch, A., & Winner, B. (2021). Generation and characterization of an endogenously tagged SPG11-human iPSC line by CRISPR/Cas9 mediated knock-in. Stem Cell Res, 56, 102520. https://doi.org/10.1016/j.scr.2021.102520

Falk, S., Han, D., & Karow, M. (2021). Cellular identity through the lens of direct lineage reprogramming. Curr Opin Genet Dev, 70, 97-103. https://doi.org/10.1016/j.gde.2021.06.015

David S. Fischer, Anna C. Schaar, Fabian J. Theis. bioRxiv 2021.07.11.451750; doi: https://doi.org/10.1101/2021.07.11.451750

Rothhammer-Hampl, T., Liesenberg, F., Hansen, N., Hoja, S., Delic, S., Reifenberger, G., & Riemenschneider, M. J. (2021). Frequent Epigenetic Inactivation of DIRAS-1 and DIRAS-2 Contributes to Chemo-Resistance in Gliomas. Cancers (Basel), 13(20). https://doi.org/10.3390/cancers13205113

Zappia, L., & Theis, F. J. (2021). Over 1000 tools reveal trends in the single-cell RNA-seq analysis landscape. Genome Biol, 22(1), 301.https://doi.org/10.1186/s13059-021-02519-4

Herrero-Navarro, A., Puche-Aroca, L., Moreno-Juan, V., Sempere-Ferrandez, A., Espinosa, A., Susin, R., Torres-Masjoan, L., Leyva-Diaz, E., Karow, M., & Figueres-Onate, M. (2020). Astrocytes and neurons share brain region-specific transcriptional signatures. bioRxiv.

Regensburger, M., Stemick, J., Masliah, E., Kohl, Z., & Winner, B. (2020). Intracellular A53T Mutant alpha-Synuclein Impairs Adult Hippocampal Newborn Neuron Integration. Front Cell Dev Biol, 8, 561963. https://doi.org/10.3389/fcell.2020.561963

Frob, F., & Wegner, M. (2020). The role of chromatin remodeling complexes in Schwann cell development. Glia, 68(8), 1596-1603. https://doi.org/10.1002/glia.23766

Lampert, A., Bennett, D. L., McDermott, L. A., Neureiter, A., Eberhardt, E., Winner, B., & Zenke, M. (2020). Human sensory neurons derived from pluripotent stem cells for disease modelling and personalized medicine. Neurobiol Pain, 8, 100055. https://doi.org/10.1016/j.ynpai.2020.100055

Pozner, T., Regensburger, M., Engelhorn, T., Winkler, J., & Winner, B. (2020). Janus-faced spatacsin (SPG11): involvement in neurodevelopment and multisystem neurodegeneration. Brain, 143(8), 2369-2379. https://doi.org/10.1093/brain/awaa099

Lorenz, J., Rothhammer-Hampl, T., Zoubaa, S., Bumes, E., Pukrop, T., Kolbl, O., Corbacioglu, S., Schmidt, N. O., Proescholdt, M., Hau, P., & Riemenschneider, M. J. (2020). A comprehensive DNA panel next generation sequencing approach supporting diagnostics and therapy prediction in neurooncology. Acta Neuropathol Commun, 8(1), 124. https://doi.org/10.1186/s40478-020-01000-w

Simmnacher, K., Krach, F., Schneider, Y., Alecu, J. E., Mautner, L., Klein, P., Roybon, L., Prots, I., Xiang, W., & Winner, B. (2020). Unique signatures of stress-induced senescent human astrocytes. Exp Neurol, 334, 113466. https://doi.org/10.1016/j.expneurol.2020.113466

Krach, F., Bogiongko, M. E., & Winner, B. (2020). Decoding Parkinson's disease - iPSC-derived models in the OMICs era. Mol Cell Neurosci, 106, 103501. https://doi.org/10.1016/j.mcn.2020.103501

Lambrecht, V., Hanspach, J., Hoffmann, A., Seyler, L., Mennecke, A., Straub, S., Marxreiter, F., Bauerle, T., Laun, F. B., & Winkler, J. (2020). Quantitative susceptibility mapping depicts severe myelin deficit and iron deposition in a transgenic model of multiple system atrophy. Exp Neurol, 329, 113314. https://doi.org/10.1016/j.expneurol.2020.113314

Boerstler, T., Wend, H., Krumbiegel, M., Kavyanifar, A., Reis, A., Lie, D. C., Winner, B., & Turan, S. (2020). CRISPR/Cas9 mediated generation of human ARID1B heterozygous knockout hESC lines to model Coffin-Siris syndrome. Stem Cell Res, 47, 101889. https://doi.org/10.1016/j.scr.2020.101889

von Wittgenstein, J., Zheng, F., Wittmann, M. T., Balta, E. A., Ferrazzi, F., Schaffner, I., Haberle, B. M., Valero-Aracama, M. J., Koehl, M., Miranda, C. J., Kaspar, B. K., Ekici, A. B., Reis, A., Abrous, D. N., Alzheimer, C., & Lie, D. C. (2020). Sox11 is an Activity-Regulated Gene with Dentate-Gyrus-Specific Expression Upon General Neural Activation. Cereb Cortex, 30(6), 3731-3743. https://doi.org/10.1093/cercor/bhz338

Wedel, M., Frob, F., Elsesser, O., Wittmann, M. T., Lie, D. C., Reis, A., & Wegner, M. (2020). Transcription factor Tcf4 is the preferred heterodimerization partner for Olig2 in oligodendrocytes and required for differentiation. Nucleic Acids Res, 48(9), 4839-4857. https://doi.org/10.1093/nar/gkaa218

Heppt, J., Wittmann, M. T., Schaffner, I., Billmann, C., Zhang, J., Vogt-Weisenhorn, D., Prakash, N., Wurst, W., Taketo, M. M., & Lie, D. C. (2020). beta-catenin signaling modulates the tempo of dendritic growth of adult-born hippocampal neurons. EMBO J, 39(21), e104472. https://doi.org/10.15252/embj.2020104472

Braun, K., Haberle, B. M., Wittmann, M. T., & Lie, D. C. (2020). Enriched environment ameliorates adult hippocampal neurogenesis deficits in Tcf4 haploinsufficient mice. BMC Neurosci, 21(1), 50. https://doi.org/10.1186/s12868-020-00602-3

He, Z., Brazovskaja, A., Ebert, S., Camp, J. G., & Treutlein, B. (2020). CSS: cluster similarity spectrum integration of single-cell genomics data. Genome Biol, 21(1), 224.https://doi.org/10.1186/s13059-020-02147-4

Simmnacher, K., Lanfer, J., Rizo, T., Kaindl, J., Winner, B. (2020) Modeling Cell-Cell Interactions in Parkinson’s Disease Using Human Stem Cell-Based Models. Front. Cell. Neurosci. 13:571. doi: 10.3389/fncel.2019.00571

Kaindl, J., & Winner, B. (2019). Disease Modeling of Neuropsychiatric Brain Disorders Using Human Stem Cell-Based Neural Models. Curr Top Behav Neurosci, 42, 159-183. https://doi.org/10.1007/7854_2019_111

Ortega, G. C., Falk, S., Johansson, P. A., Peyre, E., Broix, L., Sahu, S. K., Hirst, W., Schlichthaerle, T., Romero, C. D. J., & Draganova, K. (2019). The centrosome protein AKNA regulates neurogenesis via microtubule organization. Nature, 567(7746), 113-117.

Simmnacher, K., Lanfer, J., Rizo, T., Kaindl, J., & Winner, B. (2019). Modeling Cell-Cell Interactions in Parkinson's Disease Using Human Stem Cell-Based Models. Front Cell Neurosci, 13, 571. https://doi.org/10.3389/fncel.2019.00571

Turan, S., Boerstler, T., Kavyanifar, A., Loskarn, S., Reis, A., Winner, B., & Lie, D. C. (2019). A novel human stem cell model for Coffin-Siris syndrome-like syndrome reveals the importance of SOX11 dosage for neuronal differentiation and survival. Hum Mol Genet, 28(15), 2589-2599. https://doi.org/10.1093/hmg/ddz089

Maroni, M., Korner, J., Schuttler, J., Winner, B., Lampert, A., & Eberhardt, E. (2019). beta1 and beta3 subunits amplify mechanosensitivity of the cardiac voltage-gated sodium channel Nav1.5. Pflugers Arch, 471(11-12), 1481-1492. https://doi.org/10.1007/s00424-019-02324-w

Alieva, M., Leidgens, V., Riemenschneider, M. J., Klein, C. A., Hau, P., & van Rheenen, J. (2019). Intravital imaging of glioma border morphology reveals distinctive cellular dynamics and contribution to tumor cell invasion. Sci Rep, 9(1), 2054. https://doi.org/10.1038/s41598-019-38625-4

Kanton, S., Boyle, M. J., He, Z., Santel, M., Weigert, A., Sanchis-Calleja, F., Guijarro, P., Sidow, L., Fleck, J. S., Han, D., Qian, Z., Heide, M., Huttner, W. B., Khaitovich, P., Paabo, S., Treutlein, B., & Camp, J. G. (2019). Organoid single-cell genomic atlas uncovers human-specific features of brain development. Nature, 574(7778), 418-422. https://doi.org/10.1038/s41586-019-1654-9

Turan, S., Börstler, T., Kavyanifar, A., Loskarn, S., Reis, A., Winner, B., Lie, D. C. (2019) A novel human stem cell model for Coffin–Siris syndrome-like syndrome reveals the importance of SOX11 dosage for neuronal differentiation and survival, Human Molecular Genetics,  2589–2599, https://doi.org/10.1093/hmg/ddz089